ALLERGY, RESPIRATORY
Folic Acid Might Offer Allergy Relief
Traffic, Dust Linked to Asthma in Kids
Asthmatics Who Quit Smoking May Reverse Lung Damage
ALTERNATIVE MEDICINE
Meditation, Yoga Might Switch Off Stress Genes
Awareness of Alternative Therapies May Be Lacking
Acupuncture Eases Breast Cancer Treatment Side Effects
ANIMAL CARE
Safe Toys for Dogs
'Comfort Dogs' Come to Emotional Rescue
Beware of Dog Bites
BONES & JOINTS
Scientists ID New Genes Tied to Crohn's Disease
Tips to Ease an Aching Back
Yoga Can Ease Lower Back Pain
CANCER
Yoga May Bring Calm to Breast Cancer Treatment
Drinking Green Tea May Slow Prostate Cancer
Many Cancer Survivors Don't Adopt Healthy Lifestyle
CAREGIVING
Tiniest Babies Carry Biggest Costs
With Age Comes Greater Risk of Hypothermia
Medication Errors Could Be Cut: Experts
CIRCULATORY SYSTEM
Grapefruit-Heavy Diet Helped Spur Dangerous Clot
Exercise Extends Life of Kidney Patients
Health Tip: Are You Anemic?
COSMETIC
Mouse Study Finds Molecule That Tells Hair to Grow
Wrinkle Fillers Need Better Label Warnings: FDA Panel
Contact Lenses Boost Kids' Self-Image
DENTAL, ORAL
Mom's Vitamin D Levels Affect Baby's Dental Health
Gum Care Helps Control Type 2 Diabetes and Its Complications
Laser Technology Spots Cavities Before They Start
DIABETES
Drug May Not Help Diabetes-Related Eye Damage
Treatment for Type 2 Diabetes Updated
Strict Blood Sugar Lowering Won't Ease Diabetes Heart Risk
DIET, NUTRITION
Cinnamon Breaks Up Brain Plaques, May Hold Key to Fighting Alzheimer’s
Eating Vegan or Raw-Vegan at Regular Restaurants
Vinegar Might Help Keep Off Pounds
DISABILITIES
Review Finds Marijuana May Help MS Patients
Could Your Cell Phone Help Shield You From Alzheimer's?
ENVIRONMENTAL HEALTH
Greener Neighborhoods Mean Slimmer Children
Household Insecticides May Be Linked to Autoimmune Diseases
Green Areas Lower Health Inequities Between Rich, Poor
EYE CARE, VISION
It's a Whole New Outlook for Cataract Patients
Drinking Green Tea May Protect Eyes
Eye Care Checkups Tied to Insurance Status
FITNESS
Barefoot Best for Running?
Be Healthy, Spend Less
Higher Fitness Levels Tied to Lower Heart, Death Risks
GASTROINTESTINAL PROBLEMS
Gum Chewing May Speed Colon Surgery Recovery
Olive Oil May Protect Against Bowel Disease
Intestinal Bacteria Trigger Immune Response
GENERAL HEALTH
A Honey of a Sinusitis Treatment
It Pays to Eat Less as You Age
Eat Light - Live Longer
HEAD & NECK
Ski Helmets Encouraged for All
Many Children Will Outgrow Headaches
Zen May Thicken Brain, Thwart Pain
HEALTH & TECHNOLOGY
Airport Full Body Scanners Pose No Health Threat: Experts
'Comfort Dogs' Come to Emotional Rescue
Subway Defibrillators Save Lives
HEARING
Noise Hurts Men's Hearing More, Study Shows
Summer Sounds Can Lead to Hearing Loss
HEART & CARDIOVASCULAR
Vitamin B3 May Help Repair Brain After a Stroke
Omega-6 Fatty Acids Can Be Good for You
Exercise May Blunt Salt's Effect on Hypertension
INFECTIOUS DISEASE
The HPV Vaccine: Preventative Medicine or Human Sacrifice?
Poor Restroom Cleaning Causes Cruise-Ship Sickness
Hand Washing 10 Times a Day May Help Keep Flu Away
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Daily Exercise at School Yields Rewards
Gene Variation Found in Boys With Delinquent Peers
Coconut Oil May Help Fight Childhood Pneumonia
MEN'S HEALTH
Soy Linked to Low Sperm Count
Whole Grains, Bran May Fight Hypertension in Men
Could Chinese Herb Be a Natural Viagra?
MENTAL HEALTH
Reminiscing Helps Build Emotional Strength
Most Depressed Teens Don't Get Treatment
Teen Internet Addicts More Likely to Self-Harm: Study
PAIN
Are We Exercising Pain Away? Not So Much.
Acupuncture, Real or Fake, Eases Back Pain
Tai Chi May Help Ease Fibromyalgia
PHYSICAL THERAPY
PREGNANCY
Music of Mozart Soothes the Preemie Baby
Expectant Mom's Exercise Keeps Newborn's Birth Weight Down
Sugary Colas Tied to Gestational Diabetes
SENIORS
Martial Arts Training May Save Seniors' Hips
Memory Loss Help from Brain Supplement Prevagen
Community Exercise Programs Boost Seniors' Strength
SEXUAL HEALTH
SLEEP DISORDERS
Meditation May Help Put Primary Insomnia to Bed
Exercising Throat Muscles May Relieve Sleep Apnea
Moderate Aerobics May Ease Insomnia Symptoms
WOMEN'S HEALTH
Caffeine in Pregnancy Associated With Low Birth Weight Risk
Supportive Weigh-In Program Keeps Pounds Off
Supplements Might Reduce Breast Cancer Risk
Add your Article

Gene Explains How High-Fructose Diets Lead to Insulin Resistance

FRIDAY, March 6 (HealthDay News) -- A gene called PGC-1b appears to play a role in insulin resistance that can be caused by consuming large amounts of high-fructose corn syrup, a sweetener found in most sodas and many processed foods.

Researchers found that mice fed a high-fructose diet were protected from insulin resistance when PGC-1b activity was blocked in the rodents' liver and fat tissue. The findings were published in the March issue of Cell Metabolism.

"There has been a remarkable increase in consumption of high-fructose corn syrup," Gerald Shulman, of the Yale School of Medicine, said in a journal news release. "Fructose is much more readily metabolized to fat in the liver than glucose is, and, in the process, can lead to nonalcoholic fatty liver disease (NAFLD)," which, in turn, leads to hepatic insulin resistance and type 2 diabetes.

High-fructose corn syrup -- a mixture of the simple sugars fructose and glucose -- came into use in the 1970s. By 2005, the average American consumed about 60 pounds of high-fructose corn syrup a year.

The study authors said their findings indicate that PGC-1b plays an important role in the development of fructose-induced insulin resistance. The gene may offer a target for new drugs to treat insulin resistance, NAFLD and hypertriglyceridemia, they concluded.

In an accompanying commentary, two experts said the study shows that PGC-1b is "a missing link between fructose intake and metabolic disorders."

"The findings ... support the emerging role of gene/environment interaction in modulating the metabolic phenotype and disease pathogenesis. Thus, perturbations of the same regulatory motif may produce vastly different metabolic responses, depending on the specific combinations of dietary nutrients," wrote Carlos Hernandez and Jiandie Lin of the University of Michigan Medical Center, in Ann Arbor.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.



-- Robert Preidt



SOURCE: Cell Press, news release, March 3, 2009

Last Updated: March 06, 2009

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