ALLERGY, RESPIRATORY
Molecule in Skin May Link Eczema and Asthma
Climate Change Could Sting Allergy, Asthma Sufferers
Keep Asthma, Allergies at Bay for the Holidays
ALTERNATIVE MEDICINE
Ginkgo No Shield Against Alzheimer's
Alternative Treatments May Boost IVF Success
Pharoah's Wine Jar Yields Medicinal Secrets
ANIMAL CARE
Beware of Dog Bites
Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe
Separation Anxiety, Canine-Style
BONES & JOINTS
Winter Is Tough on Feet
Childhood Dairy Intake Boosts Bone Health Later On
Alcohol Abuse Can Damage Bones
CANCER
Broccoli May Help Battle Breast Cancer
Higher Vitamin D Intake Could Cut Cancer Risk
Omega-3 May Safely Treat Precancerous Bowel Polyps
CAREGIVING
Recession Scrambling Health Spending in U.S.
High Rate of Rehospitalizations Costing Billions
What Moms Learned May Be Passed to Offspring
CIRCULATORY SYSTEM
Tai Chi and Qigong Offer Many Health Benefits: Review
Support Network May Play Role in Benefits of Drinking
Night Shift Work Hard on the Heart
COSMETIC
Mouse Study Finds Molecule That Tells Hair to Grow
Study Evaluates Laser Therapies for Hair Removal
What to Do If You Have Unsightly Veins
DENTAL, ORAL
Acupuncture May Ease Anxiety Over Dental Work
Rheumatoid Arthritis May Harm Gums
Amino Acid May Be Key to Strong Teeth
DIABETES
Study Shows Turmeric May Prevent Type 2 Diabetes
Fructose-Sweetened Drinks Up Metabolic Syndrome Risk
'Standard' Glucose Test May Be Wrong One for Obese Children
DIET, NUTRITION
Adults Need To Get Thier Food Facts Straight
Leafy Greens Top Risky Food List
Want to Stop Cancer? You Can, Experts Say
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Heavy Traffic Can Be Heartbreaking
Meat-Eating Dinosaurs Used Legs and Arms Like Birds
Pollution Particles Impair Blood Vessel Function
EYE CARE, VISION
Diabetic Eye Disease Rates Soaring
Unconscious Learning: In the Eye of the Beholder?
Nutrient-Rich Diet Lowers Risk of Age-Related Eye Disease
FITNESS
Marathoners Go the Distance on Heart Health
Community Exercise Programs Boost Seniors' Strength
Exercise Helps Reduce Falls in Young and Old
GASTROINTESTINAL PROBLEMS
New Yogurt May Ease Stomach Ulcers
Intestinal Bacteria Trigger Immune Response
Japanese Herbals May Ease Gastro Woes
GENERAL HEALTH
Healthy Eating While On Vacation
Whole Grains, Bran May Fight Hypertension in Men
Common Social Groups and Race, Seem to Help People Relate
HEAD & NECK
Ski Helmets Encouraged for All
Many Children Will Outgrow Headaches
Zen May Thicken Brain, Thwart Pain
HEALTH & TECHNOLOGY
E-Mailing Your Way to Healthier Habits
Using Light Therapy to Silence Harmful Brain Activity
Imaging Sheds Light on How Acupuncture Works
HEARING
Summer Sounds Can Lead to Hearing Loss
Noise Hurts Men's Hearing More, Study Shows
HEART & CARDIOVASCULAR
A Little Alcohol May Help the Heart: Studies
Years of Heavy Smoking Raises Heart Risks
Boosting Vitamin D Can Do a Heart Good
INFECTIOUS DISEASE
Hand Washing 10 Times a Day May Help Keep Flu Away
Chinese 'Devil Dung' Plant Could Be a Swine Flu Fighter
Swine Flu Now Reported in All 50 States
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
When It Comes to Toys, Shop Smart, Shop Safe
Green Tea May Help Brain Cope With Sleep Disorders
Keep Safety in Mind While Your Kids Are Cooling Off in the Water
MEN'S HEALTH
Vigorous Exercise Cuts Stroke Risk for Men, Not Women
Sunlight May Help Protect Men From Kidney Cancer
Noise Hurts Men's Hearing More, Study Shows
MENTAL HEALTH
Optimism May Boost Immune System
Consciousness Helps the Mind and Body Work Together
Chocolate a Sweet Pick-Me-Up for the Depressed
PAIN
Are We Exercising Pain Away? Not So Much.
Tai Chi May Help Ease Fibromyalgia
Alleviating Rheumatoid Arthritis
PHYSICAL THERAPY
PREGNANCY
Acupuncture May Relieve Acid Indigestation In Pregnancy
Calcium Supplements Cut Blood Lead Levels During Pregnancy
Exercise Boosts Bone Density in Breast-Feeding Moms
SENIORS
Could Your Cell Phone Help Shield You From Alzheimer's?
Seniors Cope With Sleep Loss Better Than Young Adults
Want Better Health in the New Year, Add Exercise to Your Day
SEXUAL HEALTH
SLEEP DISORDERS
Meditation May Help Put Primary Insomnia to Bed
Moderate Aerobics May Ease Insomnia Symptoms
Better Sleep, Grades Seem to Go Up
WOMEN'S HEALTH
Natural Therapies for Menopause
Calcium Helps Ward Off Colon Cancer
Whole Grains, Bran May Fight Hypertension in Men
Add your Article

Gene Explains How High-Fructose Diets Lead to Insulin Resistance

FRIDAY, March 6 (HealthDay News) -- A gene called PGC-1b appears to play a role in insulin resistance that can be caused by consuming large amounts of high-fructose corn syrup, a sweetener found in most sodas and many processed foods.

Researchers found that mice fed a high-fructose diet were protected from insulin resistance when PGC-1b activity was blocked in the rodents' liver and fat tissue. The findings were published in the March issue of Cell Metabolism.

"There has been a remarkable increase in consumption of high-fructose corn syrup," Gerald Shulman, of the Yale School of Medicine, said in a journal news release. "Fructose is much more readily metabolized to fat in the liver than glucose is, and, in the process, can lead to nonalcoholic fatty liver disease (NAFLD)," which, in turn, leads to hepatic insulin resistance and type 2 diabetes.

High-fructose corn syrup -- a mixture of the simple sugars fructose and glucose -- came into use in the 1970s. By 2005, the average American consumed about 60 pounds of high-fructose corn syrup a year.

The study authors said their findings indicate that PGC-1b plays an important role in the development of fructose-induced insulin resistance. The gene may offer a target for new drugs to treat insulin resistance, NAFLD and hypertriglyceridemia, they concluded.

In an accompanying commentary, two experts said the study shows that PGC-1b is "a missing link between fructose intake and metabolic disorders."

"The findings ... support the emerging role of gene/environment interaction in modulating the metabolic phenotype and disease pathogenesis. Thus, perturbations of the same regulatory motif may produce vastly different metabolic responses, depending on the specific combinations of dietary nutrients," wrote Carlos Hernandez and Jiandie Lin of the University of Michigan Medical Center, in Ann Arbor.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.



-- Robert Preidt



SOURCE: Cell Press, news release, March 3, 2009

Last Updated: March 06, 2009

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