ALLERGY, RESPIRATORY
Using Music and Sports to Improve Kids' Asthma
Climate Change Could Sting Allergy, Asthma Sufferers
'Safe' Ozone Levels May Not Be for Some
ALTERNATIVE MEDICINE
Animals Respond to Acupuncture's Healing Touch
U.S. Spends Billions On Alternative Medicine
Should Your Child Be Seeing a Chiropractor?
ANIMAL CARE
'Comfort Dogs' Come to Emotional Rescue
Safe Toys for Dogs
Separation Anxiety, Canine-Style
BONES & JOINTS
Too Few Screened for Abdominal Aneurysm, Study Says
Chronic Low Back Pain Is on the Rise
Heart Failure Raises Risk of Fractures
CANCER
Ginger Can Ease Nausea From Chemotherapy Treatments
Physical Activity May Prolong Survival After Colon Cancer
Healthy Behaviors Slow Functional Decline After Cancer
CAREGIVING
Simpler Sleep Apnea Treatment Seems Effective, Affordable
Hospital Practices Influence Which Moms Will Breast-Feed
Caregiving May Lengthen Life
CIRCULATORY SYSTEM
Migraines in Pregnancy Boost Vascular Risks
Salt Boosts Blood Pressure in High-Risk Patients
An Apple a Day May Help Keep Heart Disease Away
COSMETIC
New Genetic Links to Baldness Discovered
Wrinkle Fillers Need Better Label Warnings: FDA Panel
Mouse Study Finds Molecule That Tells Hair to Grow
DENTAL, ORAL
Study Links Osteoporosis Drugs to Jaw Trouble
Gum Care Helps Control Type 2 Diabetes and Its Complications
Health Tip: At Risk for Gingivitis
DIABETES
Whole Grains Take a Bite Out of Type 2 Diabetes Risk
Findings Challenge Tight Glucose Control for Critically Ill Patients
Study Shows Turmeric May Prevent Type 2 Diabetes
DIET, NUTRITION
Blueberry Drink Protects Mice From Obesity, Diabetes
Go Healthy, Not Hungry for Holiday Eating
TV Food Ads Promote Bad Diets
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Hurricane Threats: Time to Batten Down the Hatches
Home Renovations by Affluent Families Can Unleash Lead Threat
Prenatal Exposure to Traffic Pollution May Lead to Asthma
EYE CARE, VISION
Antioxidant-Rich Diet May Protect Against Eye Disease
Green Tea May Ward Off Eye Disease
Impotence Drugs Don't Harm Vision: Study
FITNESS
Almost Two-Thirds of Americans Meet Exercise Guidelines
FDA Mandates New Warnings for Botox
Strenuous Daily Workout May Keep Cancer at Bay
GASTROINTESTINAL PROBLEMS
New Yogurt May Ease Stomach Ulcers
Gum Chewing May Speed Colon Surgery Recovery
Peppermint Oil, Fiber Can Fight Irritable Bowel
GENERAL HEALTH
Soluble Fiber, But Not Bran, Soothes Irritable Bowel
Natural Oils Help Lower Body Fat For Some
Spot light on Dani Antman New Lionheart teacher
HEAD & NECK
Ski Helmets Encouraged for All
Many Children Will Outgrow Headaches
Zen May Thicken Brain, Thwart Pain
HEALTH & TECHNOLOGY
Study Suggests Link Between Cell Phones and Brain Tumors
Imaging Sheds Light on How Acupuncture Works
Magnet Therapy May Ease Hard-to-Treat Depression
HEARING
Summer Sounds Can Lead to Hearing Loss
Noise Hurts Men's Hearing More, Study Shows
HEART & CARDIOVASCULAR
Irregular Heartbeat Tied to Alzheimer's Disease
Years of Heavy Smoking Raises Heart Risks
Kids With Vitamin D Deficiency Linked to Heart Trouble
INFECTIOUS DISEASE
Swine Flu Loves a Crowd
Dry Weather Boosts Odds of Flu Outbreaks
Older Adults May Have Some Immunity to Swine Flu
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Fussy Babys Could Be Out Of Your Control
Time to Remind Teens About Sun Protection
Babies Who Eat Fish Lower Eczema Risk
MEN'S HEALTH
Eating Fast Until Full Triples Overweight Risk
Noise Hurts Men's Hearing More, Study Shows
Countdown to Hair Loss
MENTAL HEALTH
Massage Fosters Healing in Bereaved Relatives
Mind Exercise Might Help Stroke Patients
Keeping Mentally Active Seems To Keep The Brain Active
PAIN
Acupuncture, Real or Fake, Eases Back Pain
Are We Exercising Pain Away? Not So Much.
Tai Chi May Help Ease Fibromyalgia
PHYSICAL THERAPY
PREGNANCY
Breast-Feeding Benefits Moms and Babies
Expectant Mom's Exercise Keeps Newborn's Birth Weight Down
Calcium Supplements Cut Blood Lead Levels During Pregnancy
SENIORS
Nighttime Urination Linked to Higher Death Rate Among Elderly
The Healthy Habits of Centenarians
Eating Well And Keeping Active As You Grow Old Will Help You Stay Sharp
SEXUAL HEALTH
SLEEP DISORDERS
Sleeping Could Help Women Lose The Baby Fat
Better Sleep, Grades Seem to Go Up
Moderate Aerobics May Ease Insomnia Symptoms
WOMEN'S HEALTH
Sugary Colas Tied to Gestational Diabetes
Spice Compounds May Stem Tumor Growth
Woman in America Are Delaying Motherhood, Study Says
Add your Article

Gene Explains How High-Fructose Diets Lead to Insulin Resistance

FRIDAY, March 6 (HealthDay News) -- A gene called PGC-1b appears to play a role in insulin resistance that can be caused by consuming large amounts of high-fructose corn syrup, a sweetener found in most sodas and many processed foods.

Researchers found that mice fed a high-fructose diet were protected from insulin resistance when PGC-1b activity was blocked in the rodents' liver and fat tissue. The findings were published in the March issue of Cell Metabolism.

"There has been a remarkable increase in consumption of high-fructose corn syrup," Gerald Shulman, of the Yale School of Medicine, said in a journal news release. "Fructose is much more readily metabolized to fat in the liver than glucose is, and, in the process, can lead to nonalcoholic fatty liver disease (NAFLD)," which, in turn, leads to hepatic insulin resistance and type 2 diabetes.

High-fructose corn syrup -- a mixture of the simple sugars fructose and glucose -- came into use in the 1970s. By 2005, the average American consumed about 60 pounds of high-fructose corn syrup a year.

The study authors said their findings indicate that PGC-1b plays an important role in the development of fructose-induced insulin resistance. The gene may offer a target for new drugs to treat insulin resistance, NAFLD and hypertriglyceridemia, they concluded.

In an accompanying commentary, two experts said the study shows that PGC-1b is "a missing link between fructose intake and metabolic disorders."

"The findings ... support the emerging role of gene/environment interaction in modulating the metabolic phenotype and disease pathogenesis. Thus, perturbations of the same regulatory motif may produce vastly different metabolic responses, depending on the specific combinations of dietary nutrients," wrote Carlos Hernandez and Jiandie Lin of the University of Michigan Medical Center, in Ann Arbor.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance.



-- Robert Preidt



SOURCE: Cell Press, news release, March 3, 2009

Last Updated: March 06, 2009

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