ALLERGY, RESPIRATORY
New Spray Could Benefit Cystic Fibrosis Patients
Air Pollution May Raise Blood Pressure
Folic Acid Might Offer Allergy Relief
ALTERNATIVE MEDICINE
Regular Yoga May Improve Eating Habits
Pain-Relieving Powers of Acupuncture Unclear
Supplement Hampers Thyroid Cancer Treatment
ANIMAL CARE
Animals Respond to Acupuncture's Healing Touch
Separation Anxiety, Canine-Style
Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe
BONES & JOINTS
Breast-feeding Might Shield Women From Rheumatoid Arthritis
Most Kids With Type 1 Diabetes Lack Vitamin D
Study Examines How Rheumatoid Arthritis Destroys Bone
CANCER
Family History Key Player in Brain Cancer Risk
Smoking Exposure Now Linked to Colon, Breast Cancers
Ginger Can Ease Nausea From Chemotherapy Treatments
CAREGIVING
Health Tip: Benefitting From Adult Day Care
Children's Bath Products Contain Contaminants
For Dialysis Patients, More Pills = Lower Quality of Life
CIRCULATORY SYSTEM
Exercise Extends Life of Kidney Patients
Years of Exposure to Traffic Pollution Raises Blood Pressure
Health Tip: Are You Anemic?
COSMETIC
Wrinkle Fillers Need Better Label Warnings: FDA Panel
Study Evaluates Laser Therapies for Hair Removal
Contact Lenses Boost Kids' Self-Image
DENTAL, ORAL
An Oral Approach to Heart Disease
Health Tip: At Risk for Gingivitis
Gum Disease Might Boost Cancer Risk
DIABETES
'Standard' Glucose Test May Be Wrong One for Obese Children
Boosting Vitamin D Can Do a Heart Good
24 Million Americans Had Diabetes in 2007
DIET, NUTRITION
Many Cancer Survivors Don't Adopt Healthy Lifestyle
Mediterranean Diet May Help Prevent Depression
Teens Lose More Weight Using Healthy Strategies
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
U.S. Diet Needs Heart-Felt Overhaul
Topical Drugs May Pollute Waterways
FDA Faulted for Stance on Chemical in Plastics
EYE CARE, VISION
Brain Adapts to Age-Related Eye Disease
Contact Lens Cases Often Contaminated
Just Like Skin, Eyes Can 'Burn' in Strong Sun
FITNESS
Exercise As Well As Acupuncture, May Ease Polycystic Ovarian Syndrome
Study Shows Exercise Shields Against Osteoporosis
Barefoot Best for Running?
GASTROINTESTINAL PROBLEMS
New Yogurt May Ease Stomach Ulcers
Intestinal Bacteria Trigger Immune Response
New Guidelines Issued for Management of IBS
GENERAL HEALTH
Trans-Fat Ban In New York City Is Proving successful
Can You Talk Your Way to Happy?
Good Sleepers More Likely to Eat Right
HEAD & NECK
Zen May Thicken Brain, Thwart Pain
Ski Helmets Encouraged for All
Many Children Will Outgrow Headaches
HEALTH & TECHNOLOGY
Study Suggests Link Between Cell Phones and Brain Tumors
E-Mailing Your Way to Healthier Habits
Imaging Sheds Light on How Acupuncture Works
HEARING
Noise Hurts Men's Hearing More, Study Shows
Summer Sounds Can Lead to Hearing Loss
HEART & CARDIOVASCULAR
Review Confirms Links Between Diet, Heart Health
Kids With Vitamin D Deficiency Linked to Heart Trouble
Women Who Run May Benefit From Extra Folic Acid
INFECTIOUS DISEASE
Bacterial Infections May Succumb to Honey
Hand Washing 10 Times a Day May Help Keep Flu Away
More Medicinal Uses for Pomegranate
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Decline of Underweight Children in U.S. Continue to Fall
Family Medicine Cabinet Top Source Of Kid's Poisonings
Help Your Kids Stay Active
MEN'S HEALTH
Physical Activity May Prolong Survival After Colon Cancer
More Vitamin C May Mean Less Chance of Gout
Lots of Sex May Prevent Erectile Dysfunction
MENTAL HEALTH
Memory Loss Help from Brain Supplement Prevagen
Shop 'Til You Drop: You May Feel Better
Positive Brain Changes Seen After Body-Mind Meditation
PAIN
Acupuncture, Real or Fake, Eases Back Pain
Alleviating Rheumatoid Arthritis
'Cell Phone Elbow' -- A New Ill for the Wired Age
PHYSICAL THERAPY
PREGNANCY
Music of Mozart Soothes the Preemie Baby
Placebo Acupuncture Tied to Higher IVF Pregnancies
Alternative Treatments May Boost IVF Success
SENIORS
Money May Matter, Health-Wise, in Old Age
15-Point Test Gauges Alzheimer's Risk
The Healthy Habits of Centenarians
SEXUAL HEALTH
SLEEP DISORDERS
Moderate Aerobics May Ease Insomnia Symptoms
6 to 8 Hours of Shut-Eye Is Optimal for Health
Lose Weight, Sleep Apnea May Improve
WOMEN'S HEALTH
Acupuncture May Help Relieve Polycystic Ovary Syndrome
Acupuncture May Relieve Acid Indigestation In Pregnancy
Air Pollution Slows Women's Marathon Times
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Gene Plays Key Role in Clubfoot

MONDAY, Oct. 27 (HealthDay News) -- The first gene linked to clubfoot has been identified by researchers at the Washington University School of Medicine in St. Louis, who analyzed the DNA of 35 extended family members of a male infant with clubfoot.

Through their analysis, the study authors concluded that a mutation in a gene called PITX1 -- which is critical for early development of lower limbs -- was responsible for the condition. The mutation was found in all 13 affected family members and in three carriers who showed no clinical symptoms.

Other genes may also play a role in clubfoot, but this finding is an initial step toward improved genetic counseling and the development of new therapies, the researchers said. The study appears in the Nov. 7 issue of the American Journal of Human Genetics.

"To our knowledge this report is the first evidence for PITX1 mutation in human disease," Dr. Christina Gurnett, an assistant professor of neurology, of pediatrics and of orthopedic surgery, said in a university news release. "Once we identified the mutation, we proved that all of the individuals in this family with lower extremity malformations also have the mutation. Having large families to work with is very helpful in genetic research."

Clubfoot, which affects about one in 1,000 newborns, is "a complex disorder meaning that more than one gene as well as environmental factors will be discovered to play a role in its [cause]," study senior author and clubfoot specialist Dr. Matthew Dobbs, an associate professor of orthopedic surgery, said in the news release.

In about 80 percent of clubfoot cases, the cause is unknown, while a familial link plays a role in about 25 percent of cases, according to background information about the study. Males are twice as likely as females to have clubfoot, which occurs more often in the right foot. About half of cases affect both feet.

More information

The March of Dimes has more about clubfoot.



-- Robert Preidt



SOURCE: Washington University, news release, Oct. 23, 2008

Last Updated: Oct. 27, 2008

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