ALLERGY, RESPIRATORY
Asthmatics Who Quit Smoking May Reverse Lung Damage
Keep Asthma, Allergies at Bay for the Holidays
'Safe' Ozone Levels May Not Be for Some
ALTERNATIVE MEDICINE
Music Therapy For Prehistoric Man?
Acupuncture Cuts Dry Mouth in Cancer Patients
Green Tea May Help Brain Cope With Sleep Disorders
ANIMAL CARE
Animals Respond to Acupuncture's Healing Touch
Safe Toys for Dogs
Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe
BONES & JOINTS
Arthritis Hits More Than Half of Diabetics
Winter Is Tough on Feet
Scientists ID New Genes Tied to Crohn's Disease
CANCER
Many Cancer Patients Turn to Complementary Medicine
Ginger Can Ease Nausea From Chemotherapy Treatments
Women Smokers Lose 14.5 Years Off Life Span
CAREGIVING
Preventing Shaken Baby Syndrome
Few Hospitals Embracing Electronic Health Record Systems
Late-Life Fatherhood May Lower Child's Intelligence
CIRCULATORY SYSTEM
Secondhand Smoke Quickly Affects Blood Vessels
A Brisk Pace May Keep Stroke at Bay
Laughter Can Boost Heart Health
COSMETIC
Health Tip: After Liposuction
Gum Chewing May Cut Craving for Snacks
Wrinkle Fillers Need Better Label Warnings: FDA Panel
DENTAL, ORAL
Sports Drinks May Be Tough on Teeth
Rheumatoid Arthritis May Harm Gums
Gum Care Helps Control Type 2 Diabetes and Its Complications
DIABETES
Lifestyle Factors Tied to Older Adults' Diabetes Risk
Fish Twice a Week Cuts Diabetics' Kidney Risks
Older Diabetics With Depression Face Higher Death Rate
DIET, NUTRITION
Fruit Even Healthier Than Thought: Study Shows
Herb Shows Potential for Rheumatoid Arthriti
Leafy Greens Top Risky Food List
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Radiation Exposure Linked to Aggressive Thyroid Cancers
Climate Change Could Sting Allergy, Asthma Sufferers
Agent Orange Exposure Tied to Prostate Cancer Return
EYE CARE, VISION
Eye Problems, Hearing Loss May Be Linked
Unconscious Learning: In the Eye of the Beholder?
Glaucoma Treatment Can Prevent Blindness
FITNESS
Exercise in Adolescence May Cut Risk of Deadly Brain Tumor
School Phys. Ed. Injuries Up 150 Percent
Exercise Key Player in Knee Replacement Recovery
GASTROINTESTINAL PROBLEMS
Soothing Imagery May Help Rid Some Kids of Stomach Pain
Japanese Herbals May Ease Gastro Woes
Bowel Prep Harder on Women Than Men
GENERAL HEALTH
The Juice From Beetroots May Boost Stamina
Mind Exercise Might Help Stroke Patients
Spot light on Dani Antman New Lionheart teacher
HEAD & NECK
Ski Helmets Encouraged for All
Zen May Thicken Brain, Thwart Pain
Many Children Will Outgrow Headaches
HEALTH & TECHNOLOGY
Study Suggests Link Between Cell Phones and Brain Tumors
Subway Defibrillators Save Lives
E-Mailing Your Way to Healthier Habits
HEARING
Noise Hurts Men's Hearing More, Study Shows
Summer Sounds Can Lead to Hearing Loss
HEART & CARDIOVASCULAR
An Apple a Day May Help Keep Heart Disease Away
Polyunsaturated Fats Really May Lower Heart Risk
Rheumatoid Arthritis a Threat to the Heart
INFECTIOUS DISEASE
Hand Washing 10 Times a Day May Help Keep Flu Away
Grapefruit Compound Inhibits Hepatitis C Virus
Swine Flu Loves a Crowd
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Exercise Eases Obesity and Anger in Kids
Breast-Feeding May Protect a Woman's Heart
Daily Exercise at School Yields Rewards
MEN'S HEALTH
Physical Activity May Prolong Survival After Colon Cancer
The Dark Side of Vegetarianism
Whole Grains, Bran May Fight Hypertension in Men
MENTAL HEALTH
Chocolate a Sweet Pick-Me-Up for the Depressed
Optimism May Boost Immune System
A Simple 'Thank You' Brings Rewards to All
PAIN
Acupuncture, Real or Fake, Eases Back Pain
Are We Exercising Pain Away? Not So Much.
Tai Chi May Help Ease Fibromyalgia
PHYSICAL THERAPY
PREGNANCY
Prenatal Stress May Boost Baby's Asthma Risk
Pre-Pregnancy Weight Linked to Babies' Heart Problems
Placebo Acupuncture Tied to Higher IVF Pregnancies
SENIORS
Tai Chi May Help Ward Off Knee Pain in Seniors
Life Expectancy in U.S. Hits New High
For a Healthier Retirement, Work a Little
SEXUAL HEALTH
SLEEP DISORDERS
6 to 8 Hours of Shut-Eye Is Optimal for Health
Pay Attention to Signs That Say You're Too Fatigued to Drive
Moderate Aerobics May Ease Insomnia Symptoms
WOMEN'S HEALTH
Heal Your Life® Tips for Living Well
Occaisonal Dieting May Cut Breast Cancer, Study Says
Bitter Melon Extract May Slow, Stop Breast Cancer
Add your Article

Grapefruit Compound Inhibits Hepatitis C Virus

TUESDAY, May 6 (HealthDay News) -- The grapefruit flavonoid naringenin inhibits the secretion of Hepatitis C virus (HCV) in infected cells and could offer a new approach for treating the disease, according to a Harvard Medical School study.

About 3 percent of the global population is infected with HCV, which can lead to cirrhosis and liver cancer. The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study.

Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.

In this new study, researchers demonstrated that HCV is actively secreted by infected cells while bound to a very low-density lipoprotein.

"Silencing apolipoprotein B (Apo-B) mRNA in infected cells causes a 70 percent reduction in the secretion of both ApoB-100 and HCV. This ApoB-dependent HCV secretion pathway suggests a novel therapeutic approach for the treatment of HCV infection," the researchers wrote.

They then tested the grapefruit flavonoid naringenin and found it reduced HCV secretion in infected cells by 80 percent.

"The concept of supplementing HCV patients' diets with naringenin is appealing," the researchers wrote. But they noted the intestinal wall doesn't absorb naringenin well, which means therapeutic doses of the flavonoid would have to be given by injection or combined with other compounds to boost its absorption by the intestines.

The researchers also noted that naringenin and several other compounds in grapefruit have significant drug-drug interactions.

"Future studies would focus on long-term ability of naringenin and perhaps other citrus flavonoids to reduce viral load in animal models and long-term cultures of primary human hepatocytes," the researchers concluded.

The study was published in the May issue of Hepatology.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.



-- Robert Preidt



SOURCE: Hepatology, news release, April 29, 2008

Last Updated: May 06, 2008

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