ALLERGY, RESPIRATORY
Asthmatics Who Quit Smoking May Reverse Lung Damage
Overweight Moms More Likely to Have Asthmatic Kids
Traffic, Dust Linked to Asthma in Kids
ALTERNATIVE MEDICINE
Fish Oil's Benefits Remain Elusive
When Healing Becomes a Commodity
Pain-Relieving Powers of Acupuncture Unclear
ANIMAL CARE
Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe
Beware of Dog Bites
Separation Anxiety, Canine-Style
BONES & JOINTS
Rheumatoid Arthritis May Harm Gums
Put Your Best Foot Forward Next Year
Gene Plays Key Role in Clubfoot
CANCER
Massage Therapy Helps Those With Advanced Cancer
Yoga Eases Sleep Problems Among Cancer Survivors
Adding Garlic Might Cut Cancer Risk
CAREGIVING
Late-Life Fatherhood May Lower Child's Intelligence
Memory Loss Help from Brain Supplement Prevagen
U.S. Mental Health Spending Rises, But Many Still Left Out
CIRCULATORY SYSTEM
Years of Exposure to Traffic Pollution Raises Blood Pressure
An Apple a Day May Help Keep Heart Disease Away
Exercise Extends Life of Kidney Patients
COSMETIC
New Genetic Links to Baldness Discovered
Contact Lenses Boost Kids' Self-Image
Study Evaluates Laser Therapies for Hair Removal
DENTAL, ORAL
An Oral Approach to Heart Disease
Study Links Osteoporosis Drugs to Jaw Trouble
Periodontal Disease Impacts Whole Health
DIABETES
Fructose-Sweetened Drinks Up Metabolic Syndrome Risk
Whole Grains Take a Bite Out of Type 2 Diabetes Risk
Boosting Vitamin D Can Do a Heart Good
DIET, NUTRITION
Mediterranean Diet Enriched With Nuts Cuts Heart Risks
Low Vitamin D Levels May Initiate Cancer Development
Eating Healthy : You Can Live Longer
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Traffic Seems to Make Kids' Asthma Worse
Smog Standards Need Tightening, Activists Say
Ozone Pollution Taking Toll on American Lives
EYE CARE, VISION
Eye Disease, Cognitive Decline Linked in Study
Diabetic Hispanics Missing Out on Eye Exams
Nearly 18 Million Will Have Macular Degeneration by 2050
FITNESS
Want to Stop Cancer? You Can, Experts Say
Exercise Extends Life of Kidney Patients
Football Can Shrink Players
GASTROINTESTINAL PROBLEMS
Gum Chewing May Speed Colon Surgery Recovery
HRT Use Raises Risk of Stomach Trouble
Intestinal Bacteria Trigger Immune Response
GENERAL HEALTH
More Calcium And Dairy Products in Childhood Could Mean Longer Life
Have a Goal in Life? You Might Live Longer
Keep Safety in Mind While Your Kids Are Cooling Off in the Water
HEAD & NECK
Ski Helmets Encouraged for All
Zen May Thicken Brain, Thwart Pain
Many Children Will Outgrow Headaches
HEALTH & TECHNOLOGY
Subway Defibrillators Save Lives
Study Suggests Link Between Cell Phones and Brain Tumors
The Internet Is Becoming One-Stop Shopping for Health Help
HEARING
Noise Hurts Men's Hearing More, Study Shows
Summer Sounds Can Lead to Hearing Loss
HEART & CARDIOVASCULAR
Man's Best Friend Helps Mend Broken Hearts
Omega-6 Fatty Acids Can Be Good for You
Fructose Boosts Blood Pressure, Studies Find
INFECTIOUS DISEASE
Dry Weather Boosts Odds of Flu Outbreaks
Swine Flu Now Reported in All 50 States
The HPV Vaccine: Preventative Medicine or Human Sacrifice?
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Combo Treatment Eases Wheezing in Babies
Traffic Seems to Make Kids' Asthma Worse
Exercise Eases Obesity and Anger in Kids
MEN'S HEALTH
Whole Grains, Bran May Fight Hypertension in Men
Sunlight May Help Protect Men From Kidney Cancer
Eating Fast Until Full Triples Overweight Risk
MENTAL HEALTH
Meditation May Boost College Students' Learning
Music Soothes Anxiety as Well as Massage Does
Optimism May Boost Immune System
PAIN
Alleviating Rheumatoid Arthritis
Tai Chi May Help Ease Fibromyalgia
'Cell Phone Elbow' -- A New Ill for the Wired Age
PHYSICAL THERAPY
PREGNANCY
Music of Mozart Soothes the Preemie Baby
Before Conceiving, Take Folic Acid for One Full Year
Placebo Acupuncture Tied to Higher IVF Pregnancies
SENIORS
Laughter Can Stimulate a Dull Appetite
A Little Alcohol May Stave Off Alzheimer's
Money May Matter, Health-Wise, in Old Age
SEXUAL HEALTH
SLEEP DISORDERS
Pay Attention to Signs That Say You're Too Fatigued to Drive
6 to 8 Hours of Shut-Eye Is Optimal for Health
Daylight Savings: Not a Bright Time for All
WOMEN'S HEALTH
Mom and Baby Alike May Benefit From Exercise
Rheumatoid Arthritis Rising Among U.S. Women
Steady Weight Gain Boosts Late-Life Breast Cancer Risk
Add your Article

Grapefruit Compound Inhibits Hepatitis C Virus

TUESDAY, May 6 (HealthDay News) -- The grapefruit flavonoid naringenin inhibits the secretion of Hepatitis C virus (HCV) in infected cells and could offer a new approach for treating the disease, according to a Harvard Medical School study.

About 3 percent of the global population is infected with HCV, which can lead to cirrhosis and liver cancer. The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study.

Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.

In this new study, researchers demonstrated that HCV is actively secreted by infected cells while bound to a very low-density lipoprotein.

"Silencing apolipoprotein B (Apo-B) mRNA in infected cells causes a 70 percent reduction in the secretion of both ApoB-100 and HCV. This ApoB-dependent HCV secretion pathway suggests a novel therapeutic approach for the treatment of HCV infection," the researchers wrote.

They then tested the grapefruit flavonoid naringenin and found it reduced HCV secretion in infected cells by 80 percent.

"The concept of supplementing HCV patients' diets with naringenin is appealing," the researchers wrote. But they noted the intestinal wall doesn't absorb naringenin well, which means therapeutic doses of the flavonoid would have to be given by injection or combined with other compounds to boost its absorption by the intestines.

The researchers also noted that naringenin and several other compounds in grapefruit have significant drug-drug interactions.

"Future studies would focus on long-term ability of naringenin and perhaps other citrus flavonoids to reduce viral load in animal models and long-term cultures of primary human hepatocytes," the researchers concluded.

The study was published in the May issue of Hepatology.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.



-- Robert Preidt



SOURCE: Hepatology, news release, April 29, 2008

Last Updated: May 06, 2008

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