ALLERGY, RESPIRATORY
Keep Asthma, Allergies at Bay for the Holidays
New Spray Could Benefit Cystic Fibrosis Patients
Herbal Remedy Could Halt Peanut Allergy
ALTERNATIVE MEDICINE
Regular Yoga May Improve Eating Habits
Could Chinese Herb Be a Natural Viagra?
Maggots as Good as Gel in Leg Ulcer Treatments
ANIMAL CARE
Beware of Dog Bites
Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe
Animals Respond to Acupuncture's Healing Touch
BONES & JOINTS
Frankincense Provides Relief for Osteoarthritis
Rheumatoid Arthritis May Harm Gums
Backpack Safety Should Be on Back-to-School Lists
CANCER
More Cancer Tests Mean More False-Positive Results
Study Cites Gains in Gall Bladder Cancer Treatment
Steady Weight Gain Boosts Late-Life Breast Cancer Risk
CAREGIVING
Are Hospital Mobile Phones Dialing Up Superbugs?
Baby's Sleep Position May Not Affect Severity of Head Flattening
Study of Everest Climbers Questions Oxygen Use
CIRCULATORY SYSTEM
Varicose Veins May Mask Larger Problem
Drink a Little Wine, Live a Little Longer
Tai Chi and Qigong Offer Many Health Benefits: Review
COSMETIC
New Genetic Links to Baldness Discovered
Health Tip: After Liposuction
Study Evaluates Laser Therapies for Hair Removal
DENTAL, ORAL
Gum Disease Might Boost Cancer Risk
Periodontal Disease Impacts Whole Health
Obesity Boosts Gum Disease Risk
DIABETES
Study Shows Turmeric May Prevent Type 2 Diabetes
Saliva Test Could Monitor Type 2 Diabetes
Fructose-Sweetened Drinks Up Metabolic Syndrome Risk
DIET, NUTRITION
DASH Diet Has Extra Benefits for Women's Health
The Food Irradiation Story
Caffeine May Offer Some Skin Cancer Protection
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Short-Term Air Pollution Exposure May Damage DNA
Staying Slim Is Good for the Environment
Old-Growth Forests Dying Off in U.S. West
EYE CARE, VISION
'Blind' Man Navigates Obstacle Course Without Error
Nearly 18 Million Will Have Macular Degeneration by 2050
Action-Filled Video Games Boost Adult Vision
FITNESS
Study Shows Exercise Shields Against Osteoporosis
Barefoot Best for Running?
Any Exercise Good After a Heart Attack
GASTROINTESTINAL PROBLEMS
Soothing Imagery May Help Rid Some Kids of Stomach Pain
Olive Oil May Protect Against Bowel Disease
Bowel Prep Harder on Women Than Men
GENERAL HEALTH
Zen May Thicken Brain, Thwart Pain
Hand-Washing Habits Still Need Improvement: Survey Says
Reminiscing Helps Build Emotional Strength
HEAD & NECK
Zen May Thicken Brain, Thwart Pain
Many Children Will Outgrow Headaches
Ski Helmets Encouraged for All
HEALTH & TECHNOLOGY
Magnet Therapy May Ease Hard-to-Treat Depression
'Comfort Dogs' Come to Emotional Rescue
'Cell Phone Elbow' -- A New Ill for the Wired Age
HEARING
Summer Sounds Can Lead to Hearing Loss
Noise Hurts Men's Hearing More, Study Shows
HEART & CARDIOVASCULAR
Women Who Run May Benefit From Extra Folic Acid
Arteries Age Twice as Fast in Smokers
Man's Best Friend Helps Mend Broken Hearts
INFECTIOUS DISEASE
Poor Restroom Cleaning Causes Cruise-Ship Sickness
Dry Weather Boosts Odds of Flu Outbreaks
Chinese 'Devil Dung' Plant Could Be a Swine Flu Fighter
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
3 Home Habits Help Youngsters Stay Slim
Obese Children More Likely to Suffer Lower Body Injuries
Protect Your Kids From Swine Flu While at Camp
MEN'S HEALTH
Varicose Veins May Mask Larger Problem
Strenuous Daily Workout May Keep Cancer at Bay
Vigorous Exercise Cuts Stroke Risk for Men, Not Women
MENTAL HEALTH
Chocolate a Sweet Pick-Me-Up for the Depressed
The Unmedicated Mind
Memory Loss Help from Brain Supplement Prevagen
PAIN
Alleviating Rheumatoid Arthritis
'Cell Phone Elbow' -- A New Ill for the Wired Age
Acupuncture, Real or Fake, Eases Back Pain
PHYSICAL THERAPY
PREGNANCY
Music of Mozart Soothes the Preemie Baby
Yoga's Benefits Outweigh Risks for Pregnant Women
Acupuncture May Relieve Acid Indigestation In Pregnancy
SENIORS
Money May Matter, Health-Wise, in Old Age
More Whole Grains May Mean Less Fat
Many Cancer Survivors Don't Adopt Healthy Lifestyle
SEXUAL HEALTH
SLEEP DISORDERS
Meditation May Help Put Primary Insomnia to Bed
Moderate Aerobics May Ease Insomnia Symptoms
Daylight Savings: Not a Bright Time for All
WOMEN'S HEALTH
For Women, Moderate Midlife Drinking Linked to Healthier Old Age
Exercise As Well As Acupuncture, May Ease Polycystic Ovarian Syndrome
Woman in America Are Delaying Motherhood, Study Says
Add your Article

Grapefruit Compound Inhibits Hepatitis C Virus

TUESDAY, May 6 (HealthDay News) -- The grapefruit flavonoid naringenin inhibits the secretion of Hepatitis C virus (HCV) in infected cells and could offer a new approach for treating the disease, according to a Harvard Medical School study.

About 3 percent of the global population is infected with HCV, which can lead to cirrhosis and liver cancer. The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study.

Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.

In this new study, researchers demonstrated that HCV is actively secreted by infected cells while bound to a very low-density lipoprotein.

"Silencing apolipoprotein B (Apo-B) mRNA in infected cells causes a 70 percent reduction in the secretion of both ApoB-100 and HCV. This ApoB-dependent HCV secretion pathway suggests a novel therapeutic approach for the treatment of HCV infection," the researchers wrote.

They then tested the grapefruit flavonoid naringenin and found it reduced HCV secretion in infected cells by 80 percent.

"The concept of supplementing HCV patients' diets with naringenin is appealing," the researchers wrote. But they noted the intestinal wall doesn't absorb naringenin well, which means therapeutic doses of the flavonoid would have to be given by injection or combined with other compounds to boost its absorption by the intestines.

The researchers also noted that naringenin and several other compounds in grapefruit have significant drug-drug interactions.

"Future studies would focus on long-term ability of naringenin and perhaps other citrus flavonoids to reduce viral load in animal models and long-term cultures of primary human hepatocytes," the researchers concluded.

The study was published in the May issue of Hepatology.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.



-- Robert Preidt



SOURCE: Hepatology, news release, April 29, 2008

Last Updated: May 06, 2008

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