ALLERGY, RESPIRATORY
Herbal Remedy Could Halt Peanut Allergy
Overweight Moms More Likely to Have Asthmatic Kids
New Spray Could Benefit Cystic Fibrosis Patients
ALTERNATIVE MEDICINE
Meditation May Boost Short-Term Visual Memory
Spot light on Dani Antman New Lionheart teacher
Acupuncture May Ease Depression During Pregnancy
ANIMAL CARE
Safe Toys for Dogs
Animals Respond to Acupuncture's Healing Touch
'Comfort Dogs' Come to Emotional Rescue
BONES & JOINTS
Rheumatoid Arthritis Hits Women Harder
New Clues to How Fish Oils Help Arthritis Patients
Heart Failure Raises Risk of Fractures
CANCER
Wristbands May Lessen Nausea After Radiation
Many Ignore Symptoms of Bladder Trouble
Acupuncture May Help Relieve Polycystic Ovary Syndrome
CAREGIVING
Transition From Home to Hospital Rarely Seamless
Falls Are Top Cause of Injury, Death Among Elderly
Critically Ill Patients Lack Vitamin D
CIRCULATORY SYSTEM
Salt Boosts Blood Pressure in High-Risk Patients
An Apple a Day May Help Keep Heart Disease Away
Walk 100 Steps a Minute for 'Moderate' Exercise
COSMETIC
Contact Lenses Boost Kids' Self-Image
Wrinkle Fillers Need Better Label Warnings: FDA Panel
Science May Banish Bad Hair Days
DENTAL, ORAL
Laser Technology Spots Cavities Before They Start
Gummy Bears Join Cavity Fight
Acid Drinks Blamed for Increase in Tooth Erosion
DIABETES
Fish Twice a Week Cuts Diabetics' Kidney Risks
Diabetes Linked to Cognitive Problems
Vitamin K Slows Insulin Resistance in Older Men
DIET, NUTRITION
Antioxidants Abound in Cereals, Popcorn, Whole-Grain Snacks
Many Cancer Survivors Don't Adopt Healthy Lifestyle
6 Million U.S. Kids Lack Enough Vitamin D
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Controversial Chemical Lingers Longer in the Body
Global Warming Linked to Heightened Kidney Stone Risk
Air Quality Better in Northeast, Midwest
EYE CARE, VISION
Vision Test for Young Children Called Unreliable
Impotence Drugs Don't Harm Vision: Study
Contact Lens Cases Often Contaminated
FITNESS
As Temperature Plummets, It's Still Safe to Exercise
Will the Wii Keep You Fit?
School Phys. Ed. Injuries Up 150 Percent
GASTROINTESTINAL PROBLEMS
New Yogurt May Ease Stomach Ulcers
Soothing Imagery May Help Rid Some Kids of Stomach Pain
New Guidelines Issued for Management of IBS
GENERAL HEALTH
Household Insecticides May Be Linked to Autoimmune Diseases
Simple Exercise Precautions To Help Keep Baby Boomers Fit
Quit Smoking the Holistic Way
HEAD & NECK
Many Children Will Outgrow Headaches
Ski Helmets Encouraged for All
Zen May Thicken Brain, Thwart Pain
HEALTH & TECHNOLOGY
Save Your Aging Brain, Try Surfing The Web
'Cell Phone Elbow' -- A New Ill for the Wired Age
Study Suggests Link Between Cell Phones and Brain Tumors
HEARING
Summer Sounds Can Lead to Hearing Loss
Noise Hurts Men's Hearing More, Study Shows
HEART & CARDIOVASCULAR
A Little Alcohol May Help the Heart: Studies
Polyunsaturated Fats Really May Lower Heart Risk
Drinking Your Way to Health? Perhaps Not
INFECTIOUS DISEASE
Older Adults May Have Some Immunity to Swine Flu
Hand Washing 10 Times a Day May Help Keep Flu Away
Grapefruit Compound Inhibits Hepatitis C Virus
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Exercise During Pregnancy Keeps Newborn Size Normal
Soothing Imagery May Help Rid Some Kids of Stomach Pain
Standard IQ Test May Underestimate People With Autism
MEN'S HEALTH
Eating Fast Until Full Triples Overweight Risk
Strenuous Daily Workout May Keep Cancer at Bay
Vigorous Exercise Cuts Stroke Risk for Men, Not Women
MENTAL HEALTH
Using the Mind to Heal the Heart
Vitamin C Protects Some Elderly Men From Bone Loss
Consciousness Helps the Mind and Body Work Together
PAIN
Acupuncture, Real or Fake, Eases Back Pain
Are We Exercising Pain Away? Not So Much.
Alleviating Rheumatoid Arthritis
PHYSICAL THERAPY
PREGNANCY
Alternative Treatments May Boost IVF Success
Exercise As Well As Acupuncture, May Ease Polycystic Ovarian Syndrome
Woman in America Are Delaying Motherhood, Study Says
SENIORS
Could Your Cell Phone Help Shield You From Alzheimer's?
Tai Chi and Qigong Offer Many Health Benefits: Review
Life Expectancy in U.S. Hits New High
SEXUAL HEALTH
SLEEP DISORDERS
Meditation May Help Put Primary Insomnia to Bed
Exercising Throat Muscles May Relieve Sleep Apnea
Sleeping Could Help Women Lose The Baby Fat
WOMEN'S HEALTH
Air Pollution Slows Women's Marathon Times
Prenatal Stress May Boost Baby's Asthma Risk
Caffeine in Pregnancy Associated With Low Birth Weight Risk
Add your Article

Grapefruit Compound Inhibits Hepatitis C Virus

TUESDAY, May 6 (HealthDay News) -- The grapefruit flavonoid naringenin inhibits the secretion of Hepatitis C virus (HCV) in infected cells and could offer a new approach for treating the disease, according to a Harvard Medical School study.

About 3 percent of the global population is infected with HCV, which can lead to cirrhosis and liver cancer. The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study.

Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.

In this new study, researchers demonstrated that HCV is actively secreted by infected cells while bound to a very low-density lipoprotein.

"Silencing apolipoprotein B (Apo-B) mRNA in infected cells causes a 70 percent reduction in the secretion of both ApoB-100 and HCV. This ApoB-dependent HCV secretion pathway suggests a novel therapeutic approach for the treatment of HCV infection," the researchers wrote.

They then tested the grapefruit flavonoid naringenin and found it reduced HCV secretion in infected cells by 80 percent.

"The concept of supplementing HCV patients' diets with naringenin is appealing," the researchers wrote. But they noted the intestinal wall doesn't absorb naringenin well, which means therapeutic doses of the flavonoid would have to be given by injection or combined with other compounds to boost its absorption by the intestines.

The researchers also noted that naringenin and several other compounds in grapefruit have significant drug-drug interactions.

"Future studies would focus on long-term ability of naringenin and perhaps other citrus flavonoids to reduce viral load in animal models and long-term cultures of primary human hepatocytes," the researchers concluded.

The study was published in the May issue of Hepatology.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.



-- Robert Preidt



SOURCE: Hepatology, news release, April 29, 2008

Last Updated: May 06, 2008

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