ALLERGY, RESPIRATORY
Overweight Moms More Likely to Have Asthmatic Kids
Know Your Asthma Triggers
Molecule in Skin May Link Eczema and Asthma
ALTERNATIVE MEDICINE
Maggots as Good as Gel in Leg Ulcer Treatments
No Verdict Yet on Grape Seed Extract vs. Breast Cancer
The Zen Way to Pain Relief
ANIMAL CARE
Safe Toys for Dogs
Separation Anxiety, Canine-Style
'Comfort Dogs' Come to Emotional Rescue
BONES & JOINTS
Rheumatoid Arthritis May Harm Gums
Barefoot Lifestyle Has Its Dangers
Gene Therapy May Ease Rheumatoid Arthritis
CANCER
Ginger Can Ease Nausea From Chemotherapy Treatments
Vitamin E, Selenium and Soy Won't Prevent Prostate Cancer
Some Spices Cut Cancer Risk That Comes With Grilled Burgers
CAREGIVING
Baby's Sleep Position May Not Affect Severity of Head Flattening
Newborn Screenings Now Required Across U.S.
Reduce Suffering, Urge Heart Failure Patients and Caregivers
CIRCULATORY SYSTEM
A Brisk Pace May Keep Stroke at Bay
Obesity Linked to Heart Failure Risk
Years of Exposure to Traffic Pollution Raises Blood Pressure
COSMETIC
Health Tip: After Liposuction
Contact Lenses Boost Kids' Self-Image
Wrinkle Fillers Need Better Label Warnings: FDA Panel
DENTAL, ORAL
Biological Product Shows Promise Against Gum Disease
An Oral Approach to Heart Disease
Rheumatoid Arthritis May Harm Gums
DIABETES
Exercise Protects Black Women From Type 2 Diabetes
Fructose-Sweetened Drinks Up Metabolic Syndrome Risk
Arthritis Hits More Than Half of Diabetics
DIET, NUTRITION
Heart Disease May Be Prevented By Taking Fish Oils, Study Shows
Coffee or Tea Consumption May Lower Stroke Risk
To Feel Better, Low-Fat Diet May Be Best
DISABILITIES
Could Your Cell Phone Help Shield You From Alzheimer's?
Review Finds Marijuana May Help MS Patients
ENVIRONMENTAL HEALTH
Are Medical Meetings Environmentally Unfriendly?
Hurricane Threats: Time to Batten Down the Hatches
Researchers ID Genetic Markers for Esophageal Cancer
EYE CARE, VISION
Too Much Sun, Too Few Antioxidants Spell Eye Trouble
Gene-Transfer Proves Safe for Vision Problem
Action-Filled Video Games Boost Adult Vision
FITNESS
Keep Safety in Mind While Your Kids Are Cooling Off in the Water
Many Cancer Survivors Don't Adopt Healthy Lifestyle
Marathoners Go the Distance on Heart Health
GASTROINTESTINAL PROBLEMS
Olive Oil May Protect Against Bowel Disease
Japanese Herbals May Ease Gastro Woes
Soothing Imagery May Help Rid Some Kids of Stomach Pain
GENERAL HEALTH
Regular Yoga May Improve Eating Habits
Why Am I So Tired? Could It Be Low Thyroid?
Quit Smoking the Holistic Way
HEAD & NECK
Zen May Thicken Brain, Thwart Pain
Ski Helmets Encouraged for All
Many Children Will Outgrow Headaches
HEALTH & TECHNOLOGY
Combating Myths About Seasonal Allergies
Subway Defibrillators Save Lives
'Comfort Dogs' Come to Emotional Rescue
HEARING
Summer Sounds Can Lead to Hearing Loss
Noise Hurts Men's Hearing More, Study Shows
HEART & CARDIOVASCULAR
Vitamin B3 May Help Repair Brain After a Stroke
Review Confirms Links Between Diet, Heart Health
Omega-6 Fatty Acids Can Be Good for You
INFECTIOUS DISEASE
More Medicinal Uses for Pomegranate
Chinese 'Devil Dung' Plant Could Be a Swine Flu Fighter
The HPV Vaccine: Preventative Medicine or Human Sacrifice?
INFERTILITY
Obesity May Affect Fertility in Young Womene
KID'S HEALTH
Traffic, Dust Linked to Asthma in Kids
Green Tea May Help Brain Cope With Sleep Disorders
Winter's Bitter Cold Poses Health Dangers
MEN'S HEALTH
Vigorous Exercise Cuts Stroke Risk for Men, Not Women
Could Chinese Herb Be a Natural Viagra?
Varicose Veins May Mask Larger Problem
MENTAL HEALTH
Have a Goal in Life? You Might Live Longer
Consciousness Helps the Mind and Body Work Together
Positive Brain Changes Seen After Body-Mind Meditation
PAIN
Alleviating Rheumatoid Arthritis
'Cell Phone Elbow' -- A New Ill for the Wired Age
Tai Chi May Help Ease Fibromyalgia
PHYSICAL THERAPY
PREGNANCY
Yoga's Benefits Outweigh Risks for Pregnant Women
Breast-Feeding May Protect a Woman's Heart
Mom's Extra Pregnancy Pounds May Raise Child's Heart Risks
SENIORS
Could Your Cell Phone Help Shield You From Alzheimer's?
The Healthy Habits of Centenarians
Memory Loss Help from Brain Supplement Prevagen
SEXUAL HEALTH
SLEEP DISORDERS
Better Sleep, Grades Seem to Go Up
Meditation May Help Put Primary Insomnia to Bed
Sleeping Could Help Women Lose The Baby Fat
WOMEN'S HEALTH
Flame-Retardant Chemical Linked to Conception Problems
Sugary Colas Tied to Gestational Diabetes
Simple Carbs Pose Heart Risk for Women
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Insulin Resistance Tied to Peripheral Artery Disease

MONDAY, June 16 (HealthDay News) -- A new study has found a strong association between insulin resistance and peripheral arterial disease (PAD), which leads to a four-to-five times increased risk of heart attack and stroke.

People with the highest levels of insulin resistance (often a precursor to diabetes) had nearly twice as much PAD, regardless of other cardiovascular risk factors such as diabetes. For each quartile of insulin resistance, the risk of PAD increased by about 25 percent.

According to the American Heart Association, PAD involves a narrowing of the arteries leading to the extremities, most notably the legs. It can cause cramping and tiredness in the limbs.

The researchers analyzed data from more than 3,200 adults enrolled in the U.S. National Health and Nutrition Examination Survey 1999-2004. They compared PAD incidence and insulin sensitivity using a model of insulin resistance (HOMA-IR), a test derived from fasting glucose and insulin values.

The overall prevalence of PAD was 5.5 percent. Insulin resistance was independently associated with PAD after the researchers adjusted for age, gender, race/ethnicity, hypertension, hyperlipidemia, smoking, body mass index, chronic kidney disease and blood levels of c-reactive protein, a marker of inflammation.

"We found a roughly 25 percent increase in the risk of PAD for each one-quartile increase in HOMA-IR, a finding that remained consistent despite adjustment for typical atherosclerosis risk factors related to insulin resistance such as body mass index and glycemic [blood sugar] control," study lead author Dr. Reena L. Pande, of the cardiovascular division at Brigham and Women's Hospital in Boston, said in a prepared statement.

"Even after excluding subjects with diabetes, there were graded increases in PAD prevalence with increasing HOMA-IR quartiles, supporting prior observations that PAD is associated with the metabolic syndrome and glucose intolerance, both surrogate markers of insulin resistance.

"Further, the association persisted after adjustment for diabetes or hemoglobin A1c, another measure of blood sugar control, indicating that insulin resistance may play a role in PAD along the entire spectrum of insulin resistance, quite distinct from the impact of diabetes," Pande said.

The study was published in the journal Circulation.

"For doctors and patients, our study highlights the role of insulin resistance in PAD and gives us a snapshot of the association between the two diseases," Pande said. "For this to play out, however, we still need prospective studies that follow over time insulin-resistant patients to determine their risk of developing PAD."

More information

The U.S. National Heart, Lung, and Blood Institute has more about peripheral arterial disease.



-- Robert Preidt



SOURCE: American Heart Association, news release, June 16, 2008

Last Updated: June 16, 2008

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