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Keep Asthma, Allergies at Bay for the Holidays
ALTERNATIVE MEDICINE
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Higher Vitamin D Intake Could Cut Cancer Risk
Acupuncture Eases Breast Cancer Treatment Side Effects
ANIMAL CARE
Beware of Dog Bites
Separation Anxiety, Canine-Style
Rest Easy. When It Comes to Swine Flu, Your Pet Is Safe
BONES & JOINTS
For All Their Plusses, Pets Pose a Risk for Falls, Too
Vitamin C Protects Some Elderly Men From Bone Loss
Get in Step With Summer Foot Care
CANCER
Researchers ID Genetic Markers for Esophageal Cancer
Selenium, Omega-3s May Stave Off Colorectal Cancer
Many Cancer Survivors Don't Adopt Healthy Lifestyle
CAREGIVING
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Children's Bath Products Contain Contaminants
Flu Strikes a Milder Blow This Season
CIRCULATORY SYSTEM
Tai Chi and Qigong Offer Many Health Benefits: Review
Mercury in Fish Linked to High Blood Pressure
Exercise Extends Life of Kidney Patients
COSMETIC
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Contact Lenses Boost Kids' Self-Image
Mouse Study Finds Molecule That Tells Hair to Grow
DENTAL, ORAL
Biological Product Shows Promise Against Gum Disease
Most Insured Adults Worry About Health Care Costs: Poll
Holistic Dentistry-My View
DIABETES
'Standard' Glucose Test May Be Wrong One for Obese Children
Doctors Urged to Screen Diabetics for Sleep Apnea
Out-of-Control Blood Sugar May Affect Memory
DIET, NUTRITION
Atkins Diet Tougher on Heart After Weight Loss
Is Your Refrigerator Getting Enough Attention For Your Raw Food Success?
Myrrh May Lower High Cholesterol
DISABILITIES
Review Finds Marijuana May Help MS Patients
Could Your Cell Phone Help Shield You From Alzheimer's?
ENVIRONMENTAL HEALTH
Short-Term Air Pollution Exposure May Damage DNA
Main Ingredients in Household Dust Come From Outdoors
Sunken, Unexploded Bombs Pose Cancer Risk
EYE CARE, VISION
Brain Pressure More Likely to Cause Vision Loss in Men
Retinal Gene Is Linked to Childhood Blindness
Kids Think Glasses Make Others Look Smart, Honest
FITNESS
Moderate Aerobic Exercise Lowers Diabetics' Liver Fat
Weak Muscles May Cause 'Runner's Knee'
Resistance Training Boosts Mobility in Knee Arthritis Patients
GASTROINTESTINAL PROBLEMS
Olive Oil May Protect Against Bowel Disease
Peppermint Oil, Fiber Can Fight Irritable Bowel
New Yogurt May Ease Stomach Ulcers
GENERAL HEALTH
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Showerheads Harbor a Bounty of Germs
Reminiscing Helps Build Emotional Strength
HEAD & NECK
Zen May Thicken Brain, Thwart Pain
Ski Helmets Encouraged for All
Many Children Will Outgrow Headaches
HEALTH & TECHNOLOGY
Using Light Therapy to Silence Harmful Brain Activity
Imaging Sheds Light on How Acupuncture Works
E-Mailing Your Way to Healthier Habits
HEARING
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Summer Sounds Can Lead to Hearing Loss
HEART & CARDIOVASCULAR
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INFECTIOUS DISEASE
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INFERTILITY
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KID'S HEALTH
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MEN'S HEALTH
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Noise Hurts Men's Hearing More, Study Shows
MENTAL HEALTH
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PAIN
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'Cell Phone Elbow' -- A New Ill for the Wired Age
PHYSICAL THERAPY
PREGNANCY
Pre-Pregnancy Weight Linked to Babies' Heart Problems
Yoga's Benefits Outweigh Risks for Pregnant Women
Sugary Colas Tied to Gestational Diabetes
SENIORS
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SEXUAL HEALTH
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Pay Attention to Signs That Say You're Too Fatigued to Drive
Better Sleep, Grades Seem to Go Up
WOMEN'S HEALTH
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Whole Grains, Bran May Fight Hypertension in Men
Frankincense Provides Relief for Osteoarthritis
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Method for Treating Cervical Lesions May Pose Pregnancy Risks

FRIDAY, June 6 (HealthDay News) -- A popular type of surgery for removing abnormal cells from the cervix -- a problem that could lead to cervical cancer if left untreated -- may put women at risk of pregnancy complications.

Women who had this procedure, known as loop electrosurgical excision procedure, or LEEP, were at greater risk of delivering preterm babies or having a low-birth-weight infant, according to British researchers.

Doctors should use caution in treating young women with mild cervical abnormalities or precancerous cells, the study authors concluded in a paper published recently in the medical journal The Lancet.

"Women should seek detailed information on efficacy but also on long-term pregnancy-related morbidity before they consent," lead study author Dr. Maria Kyrgiou of Central Lancashire Teaching Hospitals in Preston, Great Britain, told HealthDay.

LEEP is one of several surgical techniques for removing abnormal or precancerous cells from the cervix.

After numbing the cervix with local anesthesia, an electrically charged wire loop is inserted through the vagina, explains the American College of Obstetricians and Gynecologists. The loop, acting as a scalpel, cuts away a thin layer of tissue, removing the abnormal cells.

Other methods, including cold knife conization, laser ablation and laser conization, also remove or destroy suspect tissue while preserving cervical function, the British researchers noted. But the effect of these various treatments on future fertility and pregnancies has been unclear.

To assess the potential impact, Kyrgiou and her colleagues analyzed data from 27 previous studies.

Cold knife conization, which involves the excision of a cone-shaped piece of tissue, increased the likelihood of preterm birth and delivering a low-birth-weight infant by two-and-a-half times, and tripled the risk for Caesarean section, compared with women who did not have this procedure.

LEEP increased the risk of preterm delivery and delivering a low-birth-weight infant by 70 percent and 82 percent, respectively. It nearly tripled the likelihood of premature rupturing of the cervical membranes, the study authors found.

Laser conization, where a laser is used to cut away tissue, had similar outcomes, but the findings were not statistically significant.

Laser ablation, or using a laser to destroy abnormal tissue, was the only method that didn't increase pregnancy complications, the study authors said.

But at least two women's health experts cautioned about drawing conclusions from a study that involved pooling of data from multiple retrospective studies. And one warned about comparing obstetrical results among procedures used to treat different types of lesions, or tissue abnormalities.

"The appropriate study that would answer the question would be to compare LEEP and laser used for the same kind of lesion and the same size lesion done all at one institution," said Dr. Annekathryn Goodman, associate professor of obstetrics, gynecology and reproductive biology at Harvard Medical School.

That said, Goodman underscored the importance of tailoring the treatment to the type of lesion: "So, small lesions only need small procedures, and larger lesions need big procedures." And, she added, "If the wrong treatment is done, and the lesion is not completely removed, the woman is at high risk for developing a cancer."

In her view, LEEP should be limited to treating women with high-grade precancerous lesions.

Dr. Carolyn D. Runowicz, director of the Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, agreed that LEEP is needed to treat women with significant lesions to prevent an invasive cervical cancer. Women should also get a second opinion before undergoing a procedure, she said.

But the larger message, according to Runowicz, is for patients to prevent these lesions by getting regular screenings for cervical cancer.

And with the U.S. Food and Drug Administration's 2006 approval of Gardasil, a vaccine to prevent cervical cancer, woman have a powerful weapon against lesions caused by the human papillomavirus (HPV).

"HPV vaccine is the answer," agreed Dr. Joan L. Walker, chief of gynecologic oncology at the University of Oklahoma Health Sciences Center.

-Karen Pallarito

More information

For more on LEEP, visit the American College of Obstetricians and Gynecologists.



SOURCES: Annekathryn Goodman, M.D., associate professor, obstetrics, gynecology and reproductive biology, Harvard Medical School, Boston; Carolyn D. Runowicz, M.D., director, Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington; Joan L. Walker, M.D., chief, gynecologic oncology, University of Oklahoma Health Sciences Center, Oklahoma City; American College of Obstetricians and Gynecologists, Washington, D.C.; U.S. Food and Drug Administration press release; The Lancet

Last Updated: June 06, 2008

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