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ANIMAL CARE
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BONES & JOINTS
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CANCER
Scams and Shams That Prey on Cancer Patients
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CAREGIVING
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Stressed Health Care Workers Battle 'Compassion Fatigue'
Memory Loss Help from Brain Supplement Prevagen
CIRCULATORY SYSTEM
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Migraines in Pregnancy Boost Vascular Risks
Obesity Linked to Heart Failure Risk
COSMETIC
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DENTAL, ORAL
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Acupuncture May Ease Anxiety Over Dental Work
DIABETES
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Strict Blood Sugar Lowering Won't Ease Diabetes Heart Risk
Out-of-Control Blood Sugar May Affect Memory
DIET, NUTRITION
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Breakfast Eggs Keep Folks on Diet
Eat Up, But Eat Healthy This Holiday Season
DISABILITIES
Review Finds Marijuana May Help MS Patients
Could Your Cell Phone Help Shield You From Alzheimer's?
ENVIRONMENTAL HEALTH
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Fertilizer Ban Makes a Difference
Greenhouse Gases Hazardous to Your Health
EYE CARE, VISION
Gene-Transfer Proves Safe for Vision Problem
Eye Care Checkups Tied to Insurance Status
Statin Drugs Cause Eye Disorders
FITNESS
Simple Exercise Precautions To Help Keep Baby Boomers Fit
Daily Exercise at School Yields Rewards
Eating Well And Keeping Active As You Grow Old Will Help You Stay Sharp
GASTROINTESTINAL PROBLEMS
Bowel Prep Harder on Women Than Men
Intestinal Bacteria Trigger Immune Response
Peppermint Oil, Fiber Can Fight Irritable Bowel
GENERAL HEALTH
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HEAD & NECK
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HEALTH & TECHNOLOGY
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HEARING
Summer Sounds Can Lead to Hearing Loss
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HEART & CARDIOVASCULAR
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INFECTIOUS DISEASE
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Swine Flu Is Now a Pandemic Says W.H.O.
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INFERTILITY
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KID'S HEALTH
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MEN'S HEALTH
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Exercise May Prevent Prostate Cancer: Study Shows
Strenuous Daily Workout May Keep Cancer at Bay
MENTAL HEALTH
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Meaningful Conversations Boost Kids' Language Skills
PAIN
Alleviating Rheumatoid Arthritis
Are We Exercising Pain Away? Not So Much.
Tai Chi May Help Ease Fibromyalgia
PHYSICAL THERAPY
PREGNANCY
Obesity May Affect Fertility in Young Womene
Pregnant Women Exposed To Certain Pollutants Could Lower Childs IQ
Before Conceiving, Take Folic Acid for One Full Year
SENIORS
Vitamin D May Help Keep Aging at Bay
Tai Chi May Help Ease Fibromyalgia
Eating Well And Keeping Active As You Grow Old Will Help You Stay Sharp
SEXUAL HEALTH
SLEEP DISORDERS
6 to 8 Hours of Shut-Eye Is Optimal for Health
Pay Attention to Signs That Say You're Too Fatigued to Drive
Daylight Savings: Not a Bright Time for All
WOMEN'S HEALTH
Smoking Ups Risk of Second Breast Cancer
For Women, Moderate Midlife Drinking Linked to Healthier Old Age
Air Pollution Slows Women's Marathon Times
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Study of Everest Climbers Questions Oxygen Use

WEDNESDAY, Jan. 7 (HealthDay News) -- Going to the world's most elevated natural laboratory, Mount Everest, British researchers have found that the established medical rules about the amount of oxygen needed by a body under stress might be wrong.

"Some people can tolerate extremely low levels of oxygen, much lower than we expected," said Dr. Michael P.W. Grocott, from University College London and lead author of a report in the Jan. 8 New England Journal of Medicine.

His team determined their findings on hypoxia, which is low levels of oxygen, from measurements made on 10 climbers as they went up and down Everest, whose peak of more than 29,000 feet above sea level is the highest point on earth.

The report is the first to come from a large-scale project "specifically designed to understand the differences between people and how they react to hypoxia," Grocott said. Those differences are difficult to measure in ordinary hospital laboratories, but the Everest project provided a way for "measurement of unusual people in a strange place," he added.

The researchers, from the Center for Altitude, Space and Extreme Environment Medicine at the University College London's Institute of Human Health and Performance, wanted to make blood measurements at the very peak of Everest, but the weather did not allow that. Instead, samples were taken at the highest level possible, at an altitude of about 27,559 feet. The blood oxygen readings at that level "are, to our knowledge, among the lowest ever documented in humans," the researchers wrote.

"I don't expect patients to survive in oxygen levels that we saw in these subjects," Grocott said. Yet all of them "were functioning perfectly ably," he added.

The Everest finding could lead to a change in the treatment of the hypoxia often seen in people in emergency rooms, like those suffering heart attacks.

The first rule now in such cases is to keep blood oxygen levels high by whatever means possible, Grocott noted. "But mechanical ventilation can be harmful," he said. "It can cause inflammation in the lungs. The gentler you are, the less damage you do to the lungs."

The data from the Everest study is not nearly enough to be put to use medically, Grocott said. "We are not proposing a change in clinical practice," he said. But he added that it was enough to spur a proposal for a randomized clinical trial of less aggressive oxygen-supplying treatments in some cases.

"We are currently seeking funding for such a trial in the United Kingdom," he said. "We would do the trial in people at lowest risk to hypoxia, not to those with heart attack and stroke. It would be in younger people with no vascular [blood vessel] disease, traumatically injured patients with injured lungs."

But what is seen in Everest climbers might not be true in the emergency room, said Dr. Norberto C. Gonzalez, professor of molecular and integrative physiology at the University of Kansas, who has done research on hypoxia.

The climbers in the study had spent substantial amounts of time at high altitudes, Gonzalez said. "These people are acclimatized," he said. "If you and I were exposed to this level of oxygen, we couldn't take it."

While he expressed marvel at the measurements, "as low in oxygen as you can get and still be alive," Gonzalez expressed doubt that the findings seen in experienced climbers could be extended to ordinary hospital treatment.

"I'm not so sure that you can extrapolate what happens to a healthy individual who is exposed to an extreme to someone who has many problems," he said.

-Ed Edelson

More Information

What hypoxia can do to the brain is described by the U.S. National Institute of Neurological Disorders and Stroke.



SOURCES: Michael P. W. Grocott, M.D., Center for Altitude, Space and Extreme Environment Medicine, Institute of Human Health and Performance, University College London, and senior lecturer in intensive care, University College London, England; Norberto C. Gonzalez, M.D., professor of molecular and integrative physiology, University of Kansas Medical Center, Kansas City, Kan.; Jan. 8, 2009, New England Journal of Medicine

Last Updated: Jan. 07, 2009

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Study of Everest Climbers Questions Oxygen Use
NASA

Mt. Everest from International Space Station